Scientist II, Discovery Science

Job Description: Scientist II, Discovery Science
Did you start in science because you wanted to find a discovery that would positively impact the world? Are you now tired of working on research that seems like it will never translate to the clinic? At Aria Pharmaceuticals, we use artificial intelligence to discover lifesaving medicines at blazing speed. We are seeking a scientist to work on our Discovery Science team and contribute directly to our drug discovery programs. The ideal candidate is an experienced biomedical researcher with broad knowledge of pharmacology, cell biology, and omics who is interested in harnessing that knowledge towards discovering novel treatments for a wide diversity of diseases.

About us:
Aria Pharmaceuticals (formerly twoXAR Pharmaceuticals) is a preclinical-stage pharmaceutical company discovering and developing novel small molecule therapies for complex and hard-to-treat diseases. Too many patients today are in need of breakthrough treatments across many complicated diseases – they can’t wait. That’s why at Aria, we have redefined the drug discovery approach, saving years in the process and increasing success rates 30 times higher than traditional methods. At Aria, we’ve shown promise across a diverse range of therapeutic areas with the ability to address over 1,000 diseases.

Responsibilities include

• Utilize our proprietary AI-driven software to rapidly build computational disease models. This includes: * inspecting and annotating disease-specific biomedical data (e.g. omics, EMR, and clinical trials data) * using our AI-augmented annotation processes to properly define our disease of interest * running and carefully evaluating the results of our analysis algorithms
• Examine and prioritize predicted drug discovery hits identified by our proprietary, AI-platform in a range of diseases, including oncology, immunology, and fibrosis
• Perform extensive literature and data review of drug discovery hits:
  • investigate potential mechanisms specific to the disease of interest
  • compare MoAs to preclinically or clinically tested MoAs to evaluate novelty
  • evaluate DMPK data to verify a molecule’s suitability for preclinical testing
• Effectively communicate (written and verbal) and defend research internally

Requirements

• Understanding of pharmacology, cellular biology, and omics is required
• Exquisite and demonstrated attention to detail is a must to be successful in this role
• Prior experience in a pharmaceutical R&D environment is a very significant plus
• No computational experience is necessary, though familiarity with big data and bioinformatics is a plus
• Demonstrated ability to rapidly learn new concepts
• Full-time, on-site availability in Mountain View

Qualifications

• PhD, MD, or PharmD (complete or late-stage candidate)
• 5+ years of independent biomedical research
• Startup minded: high energy, low maintenance, self-starter that is comfortable in a fast-paced environment
• Cultural fit: genuine, collaborative, innovative, data-driven, and goal-oriented

Aria Pharmaceuticals is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.