Genetic Researcher

The Genetics group at Dante Labs works across both the Drug Discovery and Clinical
Development functions, with a focus on leveraging genetics to support target identification and validation as well as clinical development projects i.e. pharmacogenetics.

This role will be responsible to run analyses, such as PheWAS, on
Dante Labs specific platforms.
The incumbent will support the development and implementation of the Genetics strategy, with a focus on the pharmacogenetic component. By working with the Therapeutic Areas and Biomarker Leaders, the incumbent will provide expert leadership and support in ensuring that genetics is being systematically, but optimally applied across Dante Labs R&D.
The successful candidate will lead efforts to ensure integration of genetics data with other data sets, using machine learning approaches, to ensure a holistic approach is used to extract maximal value from the data.

MAJOR ACCOUNTABILITIES
Priority
To develop cross-functional relationships, ensuring all projects are informed and
supported by genetic data
To lead and deliver projects for Therapeutic Areas and Early Clinical Development
To support development, implementation and integration of pharmacogenetics across
Dante Labs and work with Early Development teams and Biomarker Leaders
To generate, interpret and follow up on data
To work with the Genetics team to generate data to support projects, including running in silico analyses and coordinating wet lab work as required.

EDUCATION & QUALIFICATION
Education Level: MSc with 3 years of experience or PhD
Seven years plus experience of devising, implementing and
delivering human genetics projects. 3 years plus of
pharmaceutical industry experience, with experience of
implementing genetics support for clinical development.

COMPETENCIES

Required
- Direct experience of the application of genetics and genetic approaches to drug discovery and development
- Direct experience of working within multidisciplinary projects teams within the Pharmaceutical sector
- Direct experience of devising, implementing and leading genetics strategies to support clinical development programs i.e. pharmacogenetics. Experience with protocol/ICF development is a plus.
- Direct experience of generating, analysing and using genetic data generated through multiple platforms, including next-generation sequencing (NGS) and genome wide association studies (GWAS). Direct experience of interpreting and contextualizing genetic data for non-geneticists.


Preferred:
Experience/understanding of approaches and methods in functional genomics
Experience/understanding of ML/AI approaches